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KMID : 0613820130230030383
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Journal of Life Science
2013 Volume.23 No. 3 p.383 ~ p.388
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Whitening Effect of Extracts and Fractions from Diospyros kaki calyx
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Hwang Ju-Young
Park Tae-Soon
Son Jun-Ho
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Abstract
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This study was performed to determine the whitening effect of several solvent fractions of Diospyros kaki extracts. Fractions from ethanol extracts of D. kaki were prepared by a systematic fractionation procedure using hexane, ethyl acetate, butanol, and H₂O. The ethyl acetate fractions were used to evaluate the inhibitory effects on tyrosinase activity and melanin synthesis in B16F10 melanoma cells. Ethyl acetate fractions suppressed the expression of tyrosinase, TRP-1 and TRP-2 in B16F10 melanoma cells. These results showed that ethyl acetate fractions of D. kaki could be developed as a skin whitening material in cosmetics.
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KEYWORD
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Diospyros kaki, tyrosinase, TRP-1, TRP-2, melanin
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